Antibody Searching

There are 5 different search types on the Bio platform.

1. Sequences
2. Antibody
3. Motif
4. Fragment
5. Advanced

This article will cover Antibody Searching:

When searching and viewing patents on the Bio Platform you will need to follow a three-step process.

1. Run a sequence search with Biofilters.
2. Refine Search results using source filters.
3. View results on analytics.

Antibody Searching

Antibodies are constructed by pairing heavy and light polypeptide chains. When conducting the antibody search, you must know whether your input is classified as a heavy chain or light chain. Within the polypeptide sequences, there are complementarity-determining regions (CDR). The CDR sequence is a region of the polypeptide chain that is more easily recognizable within the genetic code. To perform an antibody search you must know if your query is a CDR chain on the heavy chain region on the antibody.

1. To begin an antibody search, select Antibody from the available search options.

2. Enter your sequence in the appropriate search field.

• • For CDR sequences you must identify the degrees of mismatch that can be identified in the results. 
    • When inputting multiple chain sequences separate the sequences with space, in the appropriate search box.

A New field has been added to the Search page, allowing you to rename your search directly from the Search page itself. This streamlines the process and saves a lot of time and effort by eliminating the need to navigate to the Search history page.

3. After inputting your search query, identify which part of the literature you want to search for the inputted query.

4. Once your search query has been entered and preferences selected the search button will be activated.

5. The results page will then display your search settings, which you can hide by toggling the arrow:

Below are the counts of similar sequences, patents, and other literature that reference the searched sequences.

Below are the Common Documents charts which show the number of patents containing the sequences you have searched.

(All the charts on the sequences are labeled and contain a description underneath the title to define the purpose of the chart.)

Below are the common sources for 'exact matches', where you can compare the number of patents/papers containing both chain sequences (shown in the top chart of the image) or compare those containing both the chain sequences and all individual CDR fragments (shown in the bottom chart of the image).

Similar charts to the above can also be found for 'similar matches':

6. Clicking on a highlighted number in your selected chart, will open the related sequences in another tab. Allowing you to view all the relevant sequences, patents, literature, and other documents.

7. When you click on a patent to view you will automatically be redirected to the analytics platform. Here you can use all the functionalities of the analytics platform to view and save the patents you are interested in.  

8. Clicking on the "common source for similar match" charts will open up the combined search results page where you can further analyze the results: