Bio Antibody R&D Module: How to use

The Antibody R&D module in Patsnap Bio allows users to input any antigen of interest and explore validated antibody-antigen relationships curated from patents and non-patent literature. This walkthrough will guide you through performing a search, filtering results, exploring sequence-level insights, and integrating deeper context across organisms, drug development, and competitive intelligence.

Step 1: Start with your antigen

On the module homepage, enter your antigen of interest using a gene/protein name, UniProt ID, or keyword.

You’ll see your recent searches displayed below the search bar (up to 200 saved per account).
Click Search to proceed.

Step 2: Explore Antibody Pairings

The search results display validated antibody–antigen pairings sourced from patents and PDB entries.

For each pairing, you’ll see:

• Source document

• Antigen name with the associated species + UniProt ID

• Antibody sequences - heavy and light chain

• Antibody sequence metadata, including:

  • Heavy and light chain sequence codes

  • Sequence IDs

• Affinity (K_D)

• EC50

• IC50

Use the filters on the left to refine by:

• Antigen name

• Source type (e.g., patents, PDB)

• Species (e.g., Homo sapiens)

• Antibody

• Affinity

• EC50

• IC50

Clicking a sequence code will take you to detailed sequence records.

Step 3: View Antigen Detail for Biological Context

Selecting an antigen (e.g., TREM2) opens a rich biological profile — this includes:

• Synonyms and target overview

• Link to antibody-antigen relationships

• Clinical trials, literature, news and patent trends

• Organism-specific details

This is particularly useful for R&D teams validating targets or exploring cross-species applications.

Step 4: Investigate Drug Pipeline Data

Click the Drug tab to review therapeutic programs targeting this antigen.

You’ll see:

• Pipeline phase (e.g., Phase 1, Phase 2)

• Originating organization (e.g., Alector, Amgen)

• Associated sequences, if available

This helps place your antibody discovery in the context of competitive activity and clinical momentum.

Step 5: Access Antibody Sequences

Use the Sequence tab to browse and copy subject sequences linked to your antigen.
You’ll see:

• Sequence codes (grouped by organism)

• DNA sequences in a scannable format

• A quick-copy button for each entry

You can also save the sequences directly to a workspace, export them as a FASTA file, or directly start a sequence search with the sequence automatically inputted by using the options at the bottom

Use this section to retrieve sequences for further alignment, custom analysis, or wet-lab validation.

Extra Info

• You can switch back to Bio Premium/Pro any time by clicking “Sequence Search” in the top navigation bar.

• Paid users see full result sets. Freemium users are limited to 5 queries and 1 result per query.