Bio Results Filters – PatSnap Help Center

When you search for a sequence, you may find thousands of similar sequences with multiple functions. Currently, you can screen those sequences using filters such as Sequence Type (protein, nucleotide), Antibody, Chemically Modified, etc., however, the scope is still quite broad.

Sequence Label Filter

The sequence feature section of the sequence listing metadata contains different forms of supplementary descriptions for a sequence, such as whether it is a CDR, whether it is a mutation, etc., and these tags can indicate different roles or functions for that sequence. Based on these tags, the newly added Sequence Label Filter will allow you to screen sequences based on functionality, enhance the readability of the sequence, and ultimately improve work efficiency. They are a great way to filter down your data set to get to a more relevant subset of data and essentially allow you to have a look at the sequence and understand its function without having to read into the document. Some examples of labels include fusion protein, primer, CDR, mutation, linker, etc. These labels can be found in the Table View, Alignment View, and also on the left-hand side of the page where all the filters are.

Sequence Type Filter

Based on the sequence listing metadata tags, the Sequence Type options have also been expanded from just nucleotide and protein to cover further classifications. Biological sequence types have been classified at a subclass level to allow users to quickly understand, filter, and locate sequences with related properties or functions. Primary classifications include protein and nucleotide while secondary classifications further break these down into sub-categories including siRNA, mRNA, etc. This feature is only available to Premium users.

Organism Filter

When conducting a sequence search, there may be thousands of results –often originating from different species. The current workflow to differentiate results from different species is to manually go into each sequence detail page and look at the Sequence Listing Info field [213] for Organism. However, this disrupts the user workflow and is time-consuming when reviewing many sequences.

Therefore, an Organism filter has been added to display the corresponding species information. This will allow users to narrow down many results to a more manageable subset that they can further analyze, save, and digest more efficiently.

Core Patents Filter

Patents are a key data type used in drug discovery and development that allows users to determine if they have the freedom to operate. To identify Core Patents protecting a given drug, users must currently run a search on Synapse which adds an additional step to the user workflow and can be time-consuming if a user has many drugs to asses. Therefore, 'Patented Drug' and 'Drug Patent Type' have been added to Bio as both a filter and field to help users screen patents. These fields are exportable, with further details available via hyperlink to Synapse from the drug detail page saving users time and effort to manually source these connections.

Family Jurisdiction Filter

Users may want to search for records that have a simple/PatSnap family member in a certain jurisdiction to get a sense of the presence there. Therefore, Simple and PatSnap Family Jurisdiction filters have been added to the "Patents" tab page to enable users to search for records that have a family member in the jurisdiction (single-record families are included). Users are also able to click on the jurisdiction to go directly to the Analytics Family View. These refinement options on the result page ultimately improve search results review efficiency.

Alignment Direction Filter

When conducting nucleic acid searches, the BLAST algorithm will automatically return the sequence of forward matching and reverse complementary pairing. However, it is difficult to filter these sequences and requires significant manual effort. Therefore, an ‘Alignment Direction’ filter has been added to the Sequence Results page to allow users to refine by "Forward Alignment" and "Reverse Complement". The filter can be used to focus on the sequences of importance to the user, for example, if there is an invention that does not involve antisense technology, then these strands may not be of interest to them.

Chemically Modified

Chemical modification of biological sequences is important in many fields such as polypeptide drugs, gene therapy, viral vectors, etc. Both researchers and IP personnel pay attention to the specific modification of the sequence described in the text, including modification position, and chemical group type. At the same time, in a patent, there will be different modification methods for the same sequence corresponding to different experimental results, which need to be clearly distinguished. At present, online chemical modification cannot directly display the position and type of chemical modification, and there is no distinction between different modification schemes of the same patent. You must currently go to the Sequence Detail page to view details of the modification and it is difficult to easily digest this information. Therefore, Where Chemically Modified is selected as 'Yes', a ”View Detail” link has been added to the Sequence Results and Detail pages to quickly view modification information. This will open a pop-up tab on the right, from which you can see more details and view modification information graphically.